The Power of Intracrinology
A major discovery in medical science and women’s health.
Intracrinology is a highly sophisticated achievement of evolution that permits tissue-specific production and inactivation of sex steroids (androgen and estrogen) for a strictly local action. The fundamental principles of Intracrinology allow for a deeper understanding of the role of hormone deficiencies in menopause and aging while offering hope for new clinical approaches to common symptoms and conditions impacting the lives of millions of women.
IntracrineAxis aims to bring the fascinating potential of Intracrine science to the forefront of modern medical practice.
“The basic science principles and application of Intracrinology are now well established and will increasingly become part of the practice of clinical medicine.”
—Roger Guillemin, M.D., Ph.D.
The Salk Institute
Atrophic Vaginal Epithelium
Sex Steroid Deficiency and Tissue Atrophy
Vaginal atrophy hurts and dyspareunia is widespread after menopause. The vaginal changes characteristic of menopause and aging are chronic and progressive—leading to significant discomfort or pain for millions of postmenopausal women.
Trophic Vaginal Epithelium
The Mechanism of Action
Tissue-specific, intracellular conversion of inactive precursor hormone to androgen and estrogen has been shown to restore the functional integrity of vaginal tissue after menopause.
A major discovery in medical science and women’s health.
The secretion of estradiol by the ovaries stops at menopause. For most women, ovarian senescence is accompanied by a significant age-related decline in adrenal dehydroepiandrosterone (DHEA) secretion by the final menstrual period.
For women, the sixth decade is marked by endocrine and intracrine changes.
After menopause, androgens and estrogens are produced in highly specific amounts in peripheral tissues that are in need of these sex steroids. DHEA (also known as prasterone) is the only source of intracellular sex steroids after menopause.